![]() Histochemical analysis and serum alkaline phosphatase estimation were done to evaluate the systemic and the local bone turnover. Decalcified histology was used to describe the callus histopathology features at the tissue level, along with the calcium in the callus, to assess the mineralization activity. A radiograph was employed for the analysis of the callus mineralization at different time intervals. In the present study, we examined the differences in the cortical bone healing over a time period of 6 weeks between the control rabbits and the rabbits which received an anabolic steroid. Clinically, bridging of the fracture site with cortices or a cortical continuity is the most commonly reported criteria for a radiological assessment of the fracture union at any injury location. This method does not disturb the normal walking activities of the rabbit. The complete disruption of the cortex and the medulla by an impact force in a pre-drilled tibial shaft is technically simple and is a highly reproducible method for creating a bone defect for normal rabbit fracture healing study. Ī fracture was created at the mid-diaphysis of the tibia in vivo, for monitoring the bone healing in rabbit. The effect of an anabolic steroid in the patients who sustain fractures and in animal models, has been evaluated sparingly, although it has been shown to restore the lean body mass, to prevent osteoporosis and to correct the impaired immune response. Īnabolic steroid produces a positive nitrogen and calcium balance, and it is an established drug for treating catabolic states. This situation leads to generalized weakness, impaired immune response and slower wound and fracture healing. The patients who sustain fractures, especially those which involve the lower limb, lose body-weight after surgery. Many patients cannot return to a normal life, which causes a serious impact on their socio-economic status. A catabolic state develops after fracture and following surgery, which contributes to a poor outcome. The functional recovery after a fracture is often incomplete, especially in the older ages. ![]() –inflammation reaction, callus formation and callus remodeling. Histochemical examination of the callus and high serum alkaline phosphatase levels on day 15 and 40 confirmed better mineralization in experimental animals.įracture healing is a specialized repair process which involves a well-characterized cascade of events, which includes three major stages i.e. Results and Conclusion: Radiographs taken on the post fracture day15 and 40 showed better healing in the Nandrolone Decanoate administrated groups as a dense periosteal bone formation and prevention of the local osteoporosis. The experimental groups were further divided into the subgroups IA and IB of equal animals, which received Nandrolone Decanoate 10 mg/kg intramuscularly, biweekly for 2 weeks and 4 weeks respectively. Methods: Fracture was produced by an impact device in 24 rabbits which were divided into experimental (I) and control (II) groups of 12 animals each. The said drug has been shown to restore the lean body mass, to prevent osteoporosis and to correct the impaired immune response, but only few studies have evaluated the effect of the same on fracture healing. Introduction: Anabolic steroid is an established drug for treating catabolic states.
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